Ammasi Periasamy, Ph.D.

Professor, Center Director

Biology, University of Virginia
B005 Physical and Life Sciences Building (PLSB), White Head Rd.,
Charlottesville, VA 22904

Brief Biosketch

Dr. Ammasi Periasamy received his M.S. in Physics (Annamalai University, Tamil Nadu) and M.S./Ph.D. in Biomedical engineering (Imaging) from the Indian Institute of Technology, Madras, India. Postdoctoral training at the Biomedical Engineering, University of Washington, Seattle. Dr. Periasamy worked at the University of North Carolina at Chapel Hill where he developed fluorescence lifetime imaging microscopy (FLIM). Dr. Periasamy joined the University of Virginia in 1996 and is currently working as a Professor of Biology and Biomedical Engineering.

Dr. Periasamy is an internationally recognized expert in advanced microscopy techniques, particularly in molecular imaging in living cells, tissue, and animal. A key area of Dr. Periasamy’s research is focused on the design and development of optical methodology including advanced light microscopy techniques to investigate/monitor exogenous and endogenous molecular interactions in live cells, tissues, and animals. His group recently developed a FLIRR (Fluorescence Lifetime Redox Ratio) to investigate metabolism and mitochondrial dysfunction in cancer cells and tissues. The FLIRR approach reduces the optical artefacts involved in metabolic imaging and improves the sensitivity of measurements in live specimens.

Dr. Periasamy is the founder and center director of the internationally known WM Keck Center for Cellular Imaging (KCCI). Dr. Periasamy is one of the pioneers in the development of fluorescence lifetime imaging microscopy (FLIM) for measuring the oscillations in cytosolic and nuclear free calcium in single intact living cells. He developed a 2- and 3-color steady state, confocal, multiphoton, and FLIM based Förster resonance energy transfer (FRET) imaging systems for protein localization in living specimens. He has published 135 articles in refereed journals and book chapters. He has given 190 invited lectures nationally and internationally. Dr. Periasamy has edited three books, series book editor on cellular and clinical imaging (8 books), Chairperson in organizing an annual International conference on Multiphoton Microscopy in the Biomedical Sciences through SPIE (since 2001) and runs a hands on training annual workshop on FLIM & FRET Microscopy at the University of Virginia, Charlottesville during March (since 2002). Dr. Periasamy was elected “Fellow” member of the SPIE Optical Society in 2012.


List of Publications