Signaling & Regulation
Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: fluorescent-labeled protein kinase C beta I.
Bastiaens PI, Jovin TM.
Cyclic AMP-dependent protein kinase binding to A-kinase anchoring proteins in living cells by fluorescence resonance energy transfer of green fluorescent protein fusion proteins.
Ruehr ML, Zakhary DR, Damron DS, Bond M.
Fluorescence lifetime imaging of receptor tyrosine kinase activity in cells.
Wouters FS, Bastiaens PI.
Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon.
Emmanouilidou E, Teschemacher AG, Pouli AE, Nicholls LI, Seward EP, Rutter GA.
Imaging protein kinase Calpha activation in cells.
Ng T, Squire A, Hansra G, Bornancin F, Prevostel C, Hanby A, Harris W, Barnes D, Schmidt S, Mellor H, Bastiaens PI, Parker PJ.
Rapid caspase-3 activation during apoptosis revealed using fluorescence-resonance energy transfer.
Tyas L, Brophy VA, Pope A, Rivett AJ, Tavar¦É JM.
Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane.
Verveer PJ, Wouters FS, Reynolds AR, Bastiaens PI.
Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting of vitamin D receptors.
Prόfer K, Racz A, Lin GC, Barsony J.
Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex.
Single-molecule imaging of EGFR signalling on the surface of living cells.
Sako Y, Minoghchi S, Yanagida T.
A genetically encoded, fluorescent indicator for cyclic AMP in living cells.
Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY, Pozzan T.
Role of lipid rafts in Shiga toxin 1 interaction with the apical surface of Caco-2 cells.
Kovbasnjuk O, Edidin M, Donowitz M.
Internalization of the epidermal growth factor receptor: role in signalling.
Using green fluorescent protein to study intracellular signalling.
Tavar¦É JM, Fletcher LM, Welsh GI.
Dimerization of receptor protein-tyrosine phosphatase alpha in living cells.
Tertoolen LG, Blanchetot C, Jiang G, Overvoorde J, Gadella TW Jr, Hunter T, den Hertog J.
Receptor-mediated activation of heterotrimeric G-proteins in living cells.
Janetopoulos C, Jin T, Devreotes P.
Persistent interactions between the two transmembrane clusters dictate the targeting and functional assembly of adenylylcyclase.
Gu C, Sorkin A, Cooper DM.
Methods for visualizing RNA processing and transport pathways in living cells.
Dirks RW, Molenaar C, Tanke HJ.
Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.
Schmid JA, Scholze P, Kudlacek O, Freissmuth M, Singer EA, Sitte HH.
Confocal ratiometric voltage imaging of cultured human keratinocytes reveals layer-specific responses to ATP.
Burgstahler R, Koegel H, Rucker F, Tracey D, Grafe P, Alzheimer C.
Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus.
Day RN, Voss TC, Enwright JF 3rd, Booker CF, Periasamy A, Schaufele F.
Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy.
Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.
Tzima E, Del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, Schwartz MA.
Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.
Kinoshita A, Whelan CM, Smith CJ, Berezovska O, Hyman BT.
Stepwise rotation of the gamma-subunit of EF(0)F(1)-ATP synthase observed by intramolecular single-molecule fluorescence resonance energy transfer.
B¦Õrsch M, Diez M, Zimmermann B, Reuter R, Gr¦Äber P.
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells.
Itoh RE, Kurokawa K, Ohba Y, Yoshizaki H, Mochizuki N, Matsuda M.
Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.
Ross K, Yang L, Dower S, Volpe F, Guesdon F.
A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility.
Legg JW, Lewis CA, Parsons M, Ng T, Isacke CM.
Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.
Mechanism of Csk-mediated down-regulation of Src family tyrosine kinases in epidermal growth factor signaling.
Matsuoka H, Nada S, Okada M.
Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells.
Jobin CM, Chen H, Lin AJ, Yacono PW, Igarashi J, Michel T, Golan DE.
Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations.
Miyakawa-Naito A, Uhl¦Én P, Lal M, Aizman O, Mikoshiba K, Brismar H, Zelenin S, Aperia A.
Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.
Larijani B, Hume AN, Tarafder AK, Seabra MC.
Membrane organization of luteinizing hormone receptors differs between actively signaling and desensitized receptors.
Hunzicker-Dunn M, Barisas G, Song J, Roess DA.
Fluorescent and colored trinitrophenylated analogs of ATP and GTP.
Ovine placental lactogen-induced heterodimerization of ovine growth hormone and prolactin receptors in living cells is demonstrated by fluorescence resonance energy transfer microscopy and leads to prolonged phosphorylation of signal transducer and activator of transcription (STAT)1 and STAT3.
Biener E, Martin C, Daniel N, Frank SJ, Centonze VE, Herman B, Djiane J, Gertler A.
The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1.
Yoon Y, Krueger EW, Oswald BJ, McNiven MA.
FRET-based analysis of TRPC subunit stoichiometry.
Amiri H, Schultz G, Schaefer M.
Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy.
Conformational rearrangements associated with the gating of the G protein-coupled potassium channel revealed by FRET microscopy.
Riven I, Kalmanzon E, Segev L, Reuveny E.
New turf for CFP/YFP FRET imaging of membrane signaling molecules.
Evans J, Yue DT.
GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta.
Ebner K, Bandion A, Binder BR, de Martin R, Schmid JA.
EGF regulation of PITP dynamics is blocked by inhibitors of phospholipase C and of the Ras-MAP kinase pathway.
Larijani B, Allen-Baume V, Morgan CP, Li M, Cockcroft S.
Simultaneous optical and electrical recording of single gramicidin channels.
Borisenko V, Lougheed T, Hesse J, Fόreder-Kitzmόller E, Fertig N, Behrends JC, Woolley GA, Schόtz GJ.
Constitutive interaction of the P2Y2 receptor with the hematopoietic cell-specific G protein G(alpha16) and evidence for receptor oligomers.
Kotevic I, Kirschner KM, Porzig H, Baltensperger K.
Imaging calpain protease activity by multiphoton FRET in living mice.
Stockholm D, Bartoli M, Sillon G, Bourg N, Davoust J, Richard I.
Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell.
Braun DC, Garfield SH, Blumberg PM.
Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium.
Xu X, Meier-Schellersheim M, Jiao X, Nelson LE, Jin T.
Fluorescence resonance energy transfer reports properties of syntaxin1a interaction with Munc18-1 in vivo.
Liu J, Ernst SA, Gladycheva SE, Lee YY, Lentz SI, Ho CS, Li Q, Stuenkel EL.
Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
von Arnim CA, Tangredi MM, Peltan ID, Lee BM, Irizarry MC, Kinoshita A, Hyman BT.
Interaction of PSD-95 with potassium channels visualized by fluorescence lifetime-based resonance energy transfer imaging.
Biskup C, Kelbauskas L, Zimmer T, Benndorf K, Bergmann A, Becker W, Ruppersberg JP, Stockklausner C, Kl¦Õcker N.
Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins.
Nagai T, Yamada S, Tominaga T, Ichikawa M, Miyawaki A.
Using GFP to image peptide hormone and neuropeptide release in vitro and in vivo.
Imaging endoplasmic reticulum calcium with a fluorescent biosensor in transgenic mice.
Hara M, Bindokas V, Lopez JP, Kaihara K, Landa LR Jr, Harbeck M, Roe MW.
Single-molecule imaging analysis of Ras activation in living cells.
Murakoshi H, Iino R, Kobayashi T, Fujiwara T, Ohshima C, Yoshimura A, Kusumi A.
Fluorescence resonance energy transfer analysis of subunit stoichiometry of the epithelial Na+ channel.
Staruschenko A, Medina JL, Patel P, Shapiro MS, Booth RE, Stockand JD.
FRET between cardiac Na+ channel subunits measured with a confocal microscope and a streak camera.
Biskup C, Zimmer T, Benndorf K.
Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells.
Romsicki Y, Reece M, Gauthier JY, Asante-Appiah E, Kennedy BP.
Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells.
Kretzschmar AK, Dinger MC, Henze C, Brocke-Heidrich K, Horn F.
Visualization of Rab5 activity in living cells using FRET microscopy.
Galperin E, Sorkin A.
Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.
Gibson SK, Gilman AG.
Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells.
Nobles M, Benians A, Tinker A.
A FRET-based calcium biosensor with fast signal kinetics and high fluorescence change.
Mank M, Reiff DF, Heim N, Friedrich MW, Borst A, Griesbeck O.
Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction.
George CH, Jundi H, Walters N, Thomas NL, West RR, Lai FA.
Highlighting protein kinase CK2 movement in living cells.
Theis-Febvre N, Martel V, Laudet B, Souchier C, Grunwald D, Cochet C, Filhol O.
Organization of calcium channel beta1a subunits in triad junctions in skeletal muscle.
Leuranguer V, Papadopoulos S, Beam KG.
Intracellular interaction between syntaxin and Munc 18-1 revealed by fluorescence resonance energy transfer.
Yerrapureddy A, Korte T, Hollmann S, Nordhoff M, Ahnert-Hilger G, Herrmann A, Veit M.
Generation of functional fluorescent BK channels by random insertion of GFP variants.
Giraldez T, Hughes TE, Sigworth FJ.
Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein.
Herrick-Davis K, Grinde E, Harrigan TJ, Mazurkiewicz JE.
CaMK-II oligomerization potential determined using CFP/YFP FRET.
Lantsman K, Tombes RM.
Mapping of C-termini of V-ATPase subunits by in vivo-FRET measurements.
Seidel T, Golldack D, Dietz KJ.
An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy.
Khakh BS, Fisher JA, Nashmi R, Bowser DN, Lester HA.
Conformations of the signal recognition particle protein Ffh from Escherichia coli as determined by FRET.
Buskiewicz I, Peske F, Wieden HJ, Gryczynski I, Rodnina MV, Wintermeyer W.
Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors.
Okumoto S, Looger LL, Micheva KD, Reimer RJ, Smith SJ, Frommer WB.
Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation.
Lommerse PH, Snaar-Jagalska BE, Spaink HP, Schmidt T.
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Cardone RA, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, Casavola V, Zaccolo M, Reshkin SJ.
Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium.
Farias SL, Gazarini ML, Melo RL, Hirata IY, Juliano MA, Juliano L, Garcia CR.
Caspase-3 sensitive signaling in vivo in apoptotic HeLa cells by chemically engineered intramolecular fluorescence resonance energy transfer mutants of green fluorescent protein.
Suzuki M, Ito Y, Sakata I, Sakai T, Husimi Y, Douglas KT.
Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.
Takao K, Okamoto K, Nakagawa T, Neve RL, Nagai T, Miyawaki A, Hashikawa T, Kobayashi S, Hayashi Y.
Elimination of environmental sensitivity in a cameleon FRET-based calcium sensor via replacement of the acceptor with Venus.
Evanko DS, Haydon PG.
Distinct NF-kappaB regulation by shear stress through Ras-dependent IkappaBalpha oscillations: real-time analysis of flow-mediated activation in live cells.
Ganguli A, Persson L, Palmer IR, Evans I, Yang L, Smallwood R, Black R, Qwarnstrom EE.
Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function.
Koneru M, Schaer D, Monu N, Ayala A, Frey AB.
Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.
Benians A, Nobles M, Hosny S, Tinker A.
Measuring calcium signaling using genetically targetable fluorescent indicators.
Palmer AE, Tsien RY.
Single- and dual-parameter FRET kinase probes based on pleckstrin.
Brumbaugh J, Schleifenbaum A, Stier G, Sattler M, Schultz C.
Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.
Fowler CE, Aryal P, Suen KF, Slesinger PA.
The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting.
Gu C, Zhou W, Puthenveedu MA, Xu M, Jan YN, Jan LY.
A FRET analysis to unravel the role of cholesterol in Rac1 and PI 3-kinase activation in the InlB/Met signalling pathway.
Seveau S, Tham TN, Payrastre B, Hoppe AD, Swanson JA, Cossart P.
Association of Kv1.5 and Kv1.3 contributes to the major voltage-dependent K+ channel in macrophages.
Vicente R, Escalada A, Villalonga N, Texid¦Ò L, Roura-Ferrer M, Mart¦Ín-Satu¦É M, L¦Òpez-Iglesias C, Soler C, Solsona C, Tamkun MM, Felipe A.
G protein-coupled receptors sense fluid shear stress in endothelial cells.
Chachisvilis M, Zhang YL, Frangos JA.
Topography of plasma membrane microdomains and its consequences for mast cell signaling.
Heneberg P, Lebduska P, Dr¦Áberov¦Á L, Korb J, Dr¦Áber P.
Signalling complexes associated with adenylyl cyclase II are assembled during their biosynthesis.
Dupr¦É DJ, Baragli A, Rebois RV, Ethier N, H¦Ébert TE.
Using quantitative fluorescence microscopy and FRET imaging to measure spatiotemporal signaling events in single living cells.
Xu X, Brzostowski JA, Jin T.
Spatio-temporal kinetics of growth hormone receptor signaling in single cells using FRET microscopy.
Biener-Ramanujan E, Ramanujan VK, Herman B, Gertler A.
GIRK channel activation involves a local rearrangement of a preformed G protein channel complex.
Riven I, Iwanir S, Reuveny E.
The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway.
S¦Ánchez-Bautista S, Mar¦Ín-Vicente C, G¦Òmez-Fern¦Ández JC, Corbal¦Án-Garc¦Ía S.
AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor.
Gardner LA, Tavalin SJ, Goehring AS, Scott JD, Bahouth SW.
C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.
Singh A, Hamedinger D, Hoda JC, Gebhart M, Koschak A, Romanin C, Striessnig J.
Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels.
David M, Richer M, Mamarbachi AM, Villeneuve LR, Dupr¦É DJ, Hebert TE.
Analysis of Ras activation in living cells with GFP-RBD.
Bivona TG, Quatela S, Philips MR.
Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.
Pidasheva S, Grant M, Canaff L, Ercan O, Kumar U, Hendy GN.
Molecular rearrangements of the Kv2.1 potassium channel termini associated with voltage gating.
Kobrinsky E, Stevens L, Kazmi Y, Wray D, Soldatov NM.
A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.
Beemiller P, Hoppe AD, Swanson JA.
Ca2+ -linked upregulation and mitochondrial production of nitric oxide in the mouse preimplantation embryo.
Manser RC, Houghton FD.
Analysis of a RanGTP-regulated gradient in mitotic somatic cells.
Kal¦Áb P, Pralle A, Isacoff EY, Heald R, Weis K.
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.
Voigt P, Dorner MB, Schaefer M.
TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB.
He L, Wu X, Siegel R, Lipsky PE.
Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging.
Yasuda R, Harvey CD, Zhong H, Sobczyk A, van Aelst L, Svoboda K.
GRIF-1-kinesin-1 interactions: a confocal microscopy study.
Pozo K, Stephenson FA.
Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1alpha.
Tateyama M, Kubo Y.
Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels.
Lopes CM, Remon JI, Matavel A, Sui JL, Keselman I, Medei E, Shen Y, Rosenhouse-Dantsker A, Rohacs T, Logothetis DE.
Real-time monitoring of dynamic intracellular Ca(2+) movement during early embryogenesis through expression of yellow cameleon.
Tsuruwaka Y, Konishi T, Miyawaki A, Takagi M.
FRET-based Ca2+ measurement in B lymphocyte by flow cytometry and confocal microscopy.
Adachi T, Tsubata T.
660. Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.
Baragli A, Grieco ML, Trieu P, Villeneuve LR, H¦Ébert TE.
Molecular perspective of antigen-mediated mast cell signaling.
Davey AM, Krise KM, Sheets ED, Heikal AA.
Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release.
Visualizing Smad1/4 signaling response to bone morphogenetic protein-4 activation by FRET biosensors.
Gromova KV, Friedrich M, Noskov A, Harms GS.
Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits.
Drenan RM, Nashmi R, Imoukhuede P, Just H, McKinney S, Lester HA.
Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation.
Ananthanarayanan B, Fosbrink M, Rahdar M, Zhang J.
Dynamic interaction between Src and C-terminal Src kinase in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton.
Vielreicher M, Harms G, Butt E, Walter U, Obergfell A.
Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 Co-immunoprecipitation and fluorescence resonance energy transfer analysis.
Baragli A, Alturaihi H, Watt HL, Abdallah A, Kumar U.
Transgenic fruit-flies expressing a FRET-based sensor for in vivo imaging of cAMP dynamics.
Lissandron V, Rossetto MG, Erbguth K, Fiala A, Daga A, Zaccolo M.
Multiple functional domains are involved in tomosyn regulation of exocytosis.
Yizhar O, Lipstein N, Gladycheva SE, Matti U, Ernst SA, Rettig J, Stuenkel EL, Ashery U.
Combining surface chemistry with a FRET-based biosensor to study the dynamics of RhoA GTPase activation in cells on patterned substrates.
Hodgson L, Chan EW, Hahn KM, Yousaf MN.
The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.
Schindl R, Frischauf I, Kahr H, Fritsch R, Krenn M, Derndl A, Vales E, Muik M, Derler I, Groschner K, Romanin C.
Heteromeric assembly of acid-sensitive ion channel and epithelial sodium channel subunits.
Meltzer RH, Kapoor N, Qadri YJ, Anderson SJ, Fuller CM, Benos DJ.
Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3).
Hillebrand M, Verrier SE, Ohlenbusch A, Sch¦Äfer A, S¦Õling HD, Wouters FS, G¦Ärtner J.
Liposome-mediated assembly of receptor signaling complexes.
Montefusco DJ, Asinas AE, Weis RM.
Epithelial Na+ channel stimulation by n-3 fatty acids requires proximity to a membrane-bound A-kinase-anchoring protein complexed with protein kinase A and phosphodiesterase.
Mies F, Spriet C, H¦Éliot L, Sariban-Sohraby S.
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.
Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara RK.
Troponin C-based biosensors: a new family of genetically encoded indicators for in vivo calcium imaging in the nervous system.
Garaschuk O, Griesbeck O, Konnerth A.
Prestin-prestin and prestin-GLUT5 interactions in HEK293T cells.
Wu X, Currall B, Yamashita T, Parker LL, Hallworth R, Zuo J.
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.
Calleja V, Alcor D, Laguerre M, Park J, Vojnovic B, Hemmings BA, Downward J, Parker PJ, Larijani B.
A regulatory role for CRM1 in the multi-directional trafficking of splicing snRNPs in the mammalian nucleus.
Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization.
McLaughlin JN, Patterson MM, Malik AB.
Unitary permeability of gap junction channels to second messengers measured by FRET microscopy.
Hernandez VH, Bortolozzi M, Pertegato V, Beltramello M, Giarin M, Zaccolo M, Pantano S, Mammano F.
Protein kinase C isoform-dependent modulation of ATP-sensitive K+ channels in mitochondrial inner membrane.
Garg V, Hu K.
Mg2+ deprivation elicits rapid Ca2+ uptake and activates Ca2+/calcineurin signaling in Saccharomyces cerevisiae.
Wiesenberger G, Steinleitner K, Malli R, Graier WF, Vormann J, Schweyen RJ, Stadler JA.
Fluorescent proteins and fluorescence resonance energy transfer (FRET) as tools in signaling research.
Schmid JA, Birbach A.
Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling.
Nizzari M, Venezia V, Repetto E, Caorsi V, Magrassi R, Gagliani MC, Carlo P, Florio T, Schettini G, Tacchetti C, Russo T, Diaspro A, Russo C.
Novel insights into the regulation of the bound and diffusible glucokinase in MIN6 beta-cells.
Baltrusch S, Lenzen S.
Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B.
Yudushkin IA, Schleifenbaum A, Kinkhabwala A, Neel BG, Schultz C, Bastiaens PI.
Mechanism of action of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization--a working hypothesis.
Dziedzicka-Wasylewska M, Faron-G¦Òrecka A, G¦Òrecki A, Kuśemider M.
Quantification of local morphodynamics and local GTPase activity by edge evolution tracking.
Tsukada Y, Aoki K, Nakamura T, Sakumura Y, Matsuda M, Ishii S.
The use of FRET microscopy to elucidate steady state channel conformational rearrangements and G protein interaction with the GIRK channels.
Raveh A, Riven I, Reuveny E.
Construction of fluorescence resonance energy transfer vectors and their application in study of structure and function of signal transducers and activators of transcription 1.
Han F, Luo Y, Ge N, Xu J.
Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.
Calloway N, Vig M, Kinet JP, Holowka D, Baird B.
Annexin A6 inhibits Ras signalling in breast cancer cells.
Vil¦Á de Muga S, Timpson P, Cubells L, Evans R, Hayes TE, Rentero C, Hegemann A, Reverter M, Leschner J, Pol A, Tebar F, Daly RJ, Enrich C, Grewal T.
Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
Bal M, Zhang J, Zaika O, Hernandez CC, Shapiro MS.
Functional stoichiometry of the unitary calcium-release-activated calcium channel.
Ji W, Xu P, Li Z, Lu J, Liu L, Zhan Y, Chen Y, Hille B, Xu T, Chen L.
FRET with multiply labeled HERG K(+) channels as a reporter of the in vivo coarse architecture of the cytoplasmic domains.
Low-power laser irradiation activates Src tyrosine kinase through reactive oxygen species-mediated signaling pathway.
Zhang J, Xing D, Gao X.
Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing.
Berchner-Pfannschmidt U, Frede S, Wotzlaw C, Fandrey J.
Nanoscale organization of hedgehog is essential for long-range signaling.
Vyas N, Goswami D, Manonmani A, Sharma P, Ranganath HA, VijayRaghavan K, Shashidhara LS, Sowdhamini R, Mayor S.
The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation.
Mallaun M, Naeher D, Daniels MA, Yachi PP, Hausmann B, Luescher IF, Gascoigne NR, Palmer E.
A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion.
Fdez E, Jowitt TA, Wang MC, Rajebhosale M, Foster K, Bella J, Baldock C, Woodman PG, Hilfiker S.
Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis.
Zhang L, Xing D, Chen M.
Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
Onesto C, Shutes A, Picard V, Schweighoffer F, Der CJ.
Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.
Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lech¦Êne P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G.
Monitoring calcium concentration in neurons with cameleon.
Liu X, Gong H, Li X, Zhou W.
Calmodulin binding to M-type K+ channels assayed by TIRF/FRET in living cells.
Bal M, Zaika O, Martin P, Shapiro MS.
Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity.
Kwok S, Lee C, S¦Ánchez SA, Hazlett TL, Gratton E, Hayashi Y.
Ligand binding induces a conformational change in ifnar1 that is propagated to its membrane-proximal domain.
Strunk JJ, Gregor I, Becker Y, Li Z, Gavutis M, Jaks E, Lamken P, Walz T, Enderlein J, Piehler J.
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling.
Vilardaga JP, Nikolaev VO, Lorenz K, Ferrandon S, Zhuang Z, Lohse MJ.
Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation.
Xia N, Thodeti CK, Hunt TP, Xu Q, Ho M, Whitesides GM, Westervelt R, Ingber DE.
Mechanisms of endoplasmic-reticulum export of glycine transporter-1 (GLYT1).
Fern¦Ández-S¦Ánchez E, D¦Íez-Guerra FJ, Cubelos B, Gim¦Énez C, Zafra F.
Heterodimerization of Hypothalamic G-Protein-Coupled Receptors Involved in Weight Regulation.
Rediger A, Tarnow P, Bickenbach A, Schaefer M, Krude H, Gruters A, Biebermann H.
Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling.
Boyer SB, Clancy SM, Terunuma M, Revilla-Sanchez R, Thomas SM, Moss SJ, Slesinger PA.
The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells.
Ljubicic S, Bezzi P, Vitale N, Regazzi R.
Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans.
Wagner OI, Esposito A, K¦Õhler B, Chen CW, Shen CP, Wu GH, Butkevich E, Mandalapu S, Wenzel D, Wouters FS, Klopfenstein DR.
Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels.
Levy S, Beharier O, Etzion Y, Mor M, Buzaglo L, Shaltiel L, Gheber LA, Kahn J, Muslin AJ, Katz A, Gitler D, Moran A.
A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition.
Hibino K, Shibata T, Yanagida T, Sako Y.
Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.
Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ.
Visualization of Ras-PI3K interaction in the endosome using BiFC.
Tsutsumi K, Fujioka Y, Tsuda M, Kawaguchi H, Ohba Y.
Dynamic localization of G proteins in Dictyostelium discoideum.
Elzie CA, Colby J, Sammons MA, Janetopoulos C.
Alternating-site mechanism of kinesin-1 characterized by single-molecule FRET using fluorescent ATP analogues.
Verbrugge S, Lechner B, Woehlke G, Peterman EJ.
NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.
Zachos NC, Li X, Kovbasnjuk O, Hogema B, Sarker R, Lee LJ, Li M, de Jonge H, Donowitz M.
Effect of Ca(v)beta subunits on structural organization of Ca(v)1.2 calcium channels.
Kobrinsky E, Abrahimi P, Duong SQ, Thomas S, Harry JB, Patel C, Lao QZ, Soldatov NM.
Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown.
Baumer Y, Spindler V, Werthmann RC, Bόnemann M, Waschke J.
PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis.
Zhang Y, Xing D, Liu L.
BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis.
Wang X, Xing D, Liu L, Chen WR.
Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3.
Ega¦Ña LA, Cuevas RA, Baust TB, Parra LA, Leak RK, Hochendoner S, Pe¦Ña K, Quiroz M, Hong WC, Dorostkar MM, Janz R, Sitte HH, Torres GE.
Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells.
Cabello N, Gand¦Ía J, Bertarelli DC, Watanabe M, Llu¦Ís C, Franco R, Ferr¦É S, Luj¦Án R, Ciruela F.
FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel.
Cornea RL, Nitu F, Gruber S, Kohler K, Satzer M, Thomas DD, Fruen BR.
Fluorescence changes reveal kinetic steps of muscarinic receptor-mediated modulation of phosphoinositides and Kv7.2/7.3 K+ channels.
Jensen JB, Lyssand JS, Hague C, Hille B.
Activation of CaMKII in single dendritic spines during long-term potentiation.
Lee SJ, Escobedo-Lozoya Y, Szatmari EM, Yasuda R.
Direct spatial control of Epac1 by cyclic AMP.
Ponsioen B, Gloerich M, Ritsma L, Rehmann H, Bos JL, Jalink K.
Genetically encoded F¦Õrster resonance energy transfer sensors for the conformation of the Src family kinase Lck.
Paster W, Paar C, Eckerstorfer P, Jakober A, Drbal K, Schόtz GJ, Sonnleitner A, Stockinger H.
In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.